Details of Protein

General Information of Protein (ID: PRT00817)
Name Pumilio homolog 3 (PUM3)
Synonyms   Click to Show/Hide Synonyms of This Protein
Pum3; D19Bwg1357e; Kiaa0020
Gene Name Pum3 Gene ID
52874
UniProt ID
Q8BKS9
Family DNA binding protein (DNBP)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MEVKGKKKFTGKSPQTSQGKNKFHKNSESSSSKTFPRKAVKEGGPKVTSKNFEKGATKPG
KKGVKQFKNKPQGGKGPKDKFQKANKFSKKRKFQPDGESDESGAKKPKWDDFKKKKKELK
QSRQLSDKTNYDIVVRAKHIWESLRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTR
VIQCFIQYGNEEQRKQAFQELQGDLVELSKAKYSRNIVKKFLMYGSKPQVAEIIRSFKGH
VRKMLRHSEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLELQPAK
LELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKPRSELIEAIREAVVYLAHT
HDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKVANGQYSHLVLLAAFDCIDDTKLVKQII
ISEIISSLPSIVNDKYGRKVLLYLMSPRDPAHTVPELIELLQKGDGNAHSKKDTAIRRRE
LLESISPALLSYLQGHTQEVVLDKSACVLVSDMLGSATGDVQPAMDAIASLAAAELHPGG
KDGELHVAEHPAGHLVLKWLLEQDKKMKESGKEGCFAKTLVERVGMKNLKSWASINRGAI
ILSSLLQSCDQEVVNKVKGGLKPLIPTLEKNKSSSRGIQTLLEKLTA
Function Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose (low concentration) addition (17.50 hours)
                      Induced Change PUM3 protein abundance levels: decrease (FC = 1.65)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Cerebral stroke [ICD-11: 8B11]
                      Details It is reported that low glucose addition causes the decrease of PUM3 protein abundance compared with control group.
References
1 Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272.

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