Details of Protein

General Information of Protein (ID: PRT00800)
Name Cathepsin D (CTSD)
Synonyms   Click to Show/Hide Synonyms of This Protein
Ctsd
Gene Name Ctsd Gene ID
.
UniProt ID
P24268
Family Hydrolases (EC 3)
EC Number   EC: 3.4.23.5  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Aspartic endopeptidases
EC: 3.4.23.5
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSS
PRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQ
PGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGEL
MLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPV
DEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTI
CLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL
Structure
5UX4
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Leucine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Leucine addition (72 hours)
                      Induced Change CTSD protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that leucine addition causes the increase of CTSD protein expression compared with control group.
References
1 Chronic exposure to leucine in vitro induces -cell dysfunction in INS-1E cells and mouse islets. J Endocrinol. 2012 Oct;215(1):79-88.

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