Details of Protein

General Information of Protein (ID: PRT00777)
Name dUTP pyrophosphatase (DUT)
Synonyms   Click to Show/Hide Synonyms of This Protein
dUTPase; dUTP pyrophosphatase; DUT
Gene Name DUT Gene ID
1854
UniProt ID
P33316
Family Hydrolases (EC 3)
EC Number   EC: 3.6.1.23  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Acid anhydride hydrolase
Acid anhydride hydrolase
EC: 3.6.1.23
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
Structure
1Q5H ; 1Q5U ; 2HQU ; 3ARA ; 3ARN ; 3EHW ; 4MZ5 ; 4MZ6 ; 5H4J
Function This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Arginine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Arginine decrease (48 hours)
                      Induced Change DUT protein abundance levels: decrease (FC = 3.1)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that arginine decrease causes the decrease of DUT protein abundance compared with control group.
References
1 Arginine deficiency in preconfluent intestinal Caco-2 cells modulates expression of proteins involved in proliferation, apoptosis, and heat shock response. Proteomics. 2007 Feb;7(4):565-577.

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