Details of Protein

General Information of Protein (ID: PRT00732)
Name Actin-related T1 (ACTRT1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Actrt1
Gene Name Actrt1 Gene ID
73360
UniProt ID
Q9D9J3
Family Actin (ACT)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MLDPARLDNPAVIFDNGSGLCKVGISGEIEPRHVINSVVGHPKFNIPSARSNRKRYFVGE
EAQCMYDGLYLHYPIERGLVTRWDDMEKLWKDLFEWELGVKPNEQPVFMTEPSLNPQETR
EKTTEIMFEKFNVPALYLCNHAVGALCASACITGLVLDSGDGVTCTVPVYEGYSLPHAIT
KLYVAGRDITEHLTRLLLAKGYTFPCILNKAVVDDIKEKLCTVSLGYKDTEKNCQQFLRK
YTLPDGNTIQMSDHLCQVPEVLFTPDHLGIHDLGISKMVCNSIMNCDTDIQENLFAEIVL
SGGTTMFPGLQDRLLKELEDLAFEGTPIKITASSDRCYSAWIGGSVMTSMTTFKQMWVTA
EDFKEYGAFVVQRKCF
Function Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change ACTRT1 protein expression levels: increase (FC = 2.00)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the increase of ACTRT1 protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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