Details of Protein

General Information of Protein (ID: PRT00724)
Name Solute carrier family 19 member 2 (SLC19A2)
Synonyms   Click to Show/Hide Synonyms of This Protein
ThTr-1; ThTr1; Solute carrier family 19 member 2; Thiamine carrier 1; TC1; SLC19A2; THT1; TRMA
Gene Name SLC19A2 Gene ID
10560
UniProt ID
O60779
Family Reduced folate carrier (RFC)
TC Number   TC: 2.A.48.1.2  (Click to Show/Hide the Complete TC Tree)
The Reduced Folate Carrier (RFC) Family
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TC: 2.A.48.1.2
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP
DKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQG
LLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILV
SVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSV
WWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWST
WGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERY
ALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
Function High-affinity transporter for the intake of thiamine.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organoheterocyclic compounds
            Thiamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC19A2
                      Induced Change Thiamine concentration: increase (FC = 5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status TRMA syndrome [ICD-11: 5C63]
                      Details It is reported that overexpression of SLC19A2 leads to the increase of thiamine levels compared with control group.
References
1 The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet. 1999 Jul;22(3):305-8.

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