Details of Protein

General Information of Protein (ID: PRT00682)
Name P2Y purinoceptor 10 (P2RY10)
Synonyms   Click to Show/Hide Synonyms of This Protein
P2Y10; P2Y-like receptor; P2RY10
Gene Name P2RY10 Gene ID
27334
UniProt ID
O00398
Family GPCR rhodopsin (GPCR-1)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLC
RFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS
ICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS
CFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQK
ALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLL
DPILYYFMASEFRDQLSRHGSSVTRSRLMSKESGSSMIG
Function Putative receptor for purines coupled to G-proteins.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Lipids and lipid-like molecules
            LysoPS(18:0/0:0) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation LysoPS(18:0/0:0) addition (1 hours)
                      Induced Change P2RY10 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that lysoPS(18:0/0:0) addition causes the increase of P2RY10 protein activity compared with control group.
References
1 TGF shedding assay: an accurate and versatile method for detecting GPCR activation. Nat Methods. 2012 Oct;9(10):1021-9.

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