Details of Protein

General Information of Protein (ID: PRT00578)
Name Solute carrier family 17 member 9 (SLC17A9)
Synonyms   Click to Show/Hide Synonyms of This Protein
SLC17A9; C20orf59
Gene Name SLC17A9 Gene ID
63910
UniProt ID
Q9BYT1
Family Sodium/anion cotransporter (SAC)
TC Number   TC: 2.A.1.14.21  (Click to Show/Hide the Complete TC Tree)
The Major Facilitator Superfamily (MFS)
The Anion:Cation Symporter (ACS) Family
TC: 2.A.1.14.21
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MQPPPDEARRDMAGDTQWSRPECQAWTGTLLLGTCLLYCARSSMPICTVSMSQDFGWNKK
EAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAF
MTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEW
YGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLILALGVLAQSRPVSRHNRVPWRRLFRKPA
VWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPWLVAIPASLFSGFLSDHL
INQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNI
QDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLV
FGQAQRVDLSSTHEDL
Function Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Nucleosides, nucleotides, and analogues
            ATP Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of SLC17A9
                      Induced Change ATP concentration: decrease (FC = 0.50)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Adrenomedullary hyperfunction [ICD-11: 5A75]
                      Details It is reported that knockdown of SLC17A9 leads to the decrease of ATP levels compared with control group.
References
1 Identification of a vesicular nucleotide transporter. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5683-6.

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