Details of Protein

General Information of Protein (ID: PRT00445)
Name Acyl-CoA thioesterase 2 (ACOT2)
Synonyms   Click to Show/Hide Synonyms of This Protein
Acyl-CoA thioesterase 2; Acyl coenzyme A thioester hydrolase; MTE-I; Very-long-chain acyl-CoA thioesterase; Acot2; Mte1
Gene Name Acot2 Gene ID
171210
UniProt ID
Q9QYR9
Family Hydrolases (EC 3)
EC Number   EC: 3.1.2.2  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Thioester hydrolase
EC: 3.1.2.2
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MVASSFAVLRASRLCQQDWKSWARLFVPPPLSTGGRTTWARTNATLSVEPEGRSCWDEPL
SIAVRGLAPEQPVTLRSALRDEKGALFRAHARYRADAGGELNLARAPALGGSFSGLEPMG
LLWAMEPERPLWRLIKRDVQTPFLVELEVLDGHEPDGGQRLAQAVHERHFLAPGVRRVPV
REGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKS
IETMHMEYFEEAVNYLRSHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVA
AVGNTISYKDETIPPVSLLRNQVKMTKDGLLDVVEALQSPLVDKKSFIPVERSDTTFLFL
VGQDDHNWKSEFYADEISKRLQAHGKEKPQIICYPAAGHYIEPPYFPLCSAGMHLLVGAN
ITFGGEPRAHAVAQVDAWQQLQTFFHKQLGSKS
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change ACOT2 protein expression levels: increase (FC = 3.20)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the increase of ACOT2 protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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