Details of Protein

General Information of Protein (ID: PRT00421)
Name Superoxide dismutase Mn (SOD Mn)
Synonyms   Click to Show/Hide Synonyms of This Protein
SOD2
Gene Name SOD2 Gene ID
6648
UniProt ID
P04179
Family Oxidoreductases (EC 1)
EC Number   EC: 1.15.1.1  (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Superoxide radical acceptor oxidoreductase
Superoxide radical acceptor oxidoreductase
EC: 1.15.1.1
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
Structure
1AP5 ; 1AP6 ; 1EM1 ; 1JA8 ; 1LUV ; 1LUW ; 1MSD ; 1N0J ; 1N0N ; 1PL4 ; 1PM9 ; 1QNM ; 1SZX ; 1VAR ; 1XDC ; 1XIL ; 1ZSP ; 1ZTE ; 1ZUQ ; 2ADP ; 2ADQ ; 2GDS ; 2P4K ; 2QKA ; 2QKC ; 3C3S ; 3C3T ; 5GXO ; 5T30 ; 5VF9
Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine addition (5 hours)
                      Induced Change SOD2 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Inflammatory bowel disease [ICD-11: DD72]
                      Details It is reported that glutamine addition causes the increase of SOD2 protein expression compared with control group.
References
1 Human duodenal proteome modulations by glutamine and antioxidants. Proteomics Clin Appl. 2010 Mar;4(3):325-36.

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