Details of Protein

General Information of Protein (ID: PRT00416)
Name Histone H4 (H4C1)
Synonyms   Click to Show/Hide Synonyms of This Protein
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4-16; H4/A; H4FA; HIST1H4A; H4/I; H4FI; HIST1H4B; H4/G; H4FG; HIST1H4C; H4/B; H4FB; HIST1H4D; H4/J; H4FJ; HIST1H4E; H4/C; H4FC; HIST1H4F; H4/H; H4FH; HIST1H4H; H4/M; H4FM; HIST1H4I; H4/E; H4FE; HIST1H4J; H4/D; H4FD; HIST1H4K; H4/K; H4FK; HIST1H4L; H4/N; H4F2; H4FN; HIST2H4; HIST2H4A; H4/O; H4FO; HIST2H4B; HIST4H4
Gene Name H4C1 Gene ID
121504
UniProt ID
P62805
Family Histone (HST)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Structure
1ZKK ; 2BQZ ; 2CV5 ; 2IG0 ; 2KWN ; 2KWO ; 2LVM ; 2QQS ; 2RJE ; 2RNY ; 2RS9 ; 3A6N ; 3AFA ; 3AN2 ; 3AV1 ; 3AV2 ; 3AYW ; 3AZE ; 3AZF ; 3AZG ; 3AZH ; 3AZI ; 3AZJ ; 3AZK ; 3AZL ; 3AZM ; 3AZN ; 3CFS ; 3CFV ; 3F9W ; 3F9X ; 3F9Y ; 3F9Z ; 3IJ1 ; 3JPX ; 3NQJ ; 3NQU ; 3O36 ; 3QBY ; 3QZS ; 3QZT ; 3QZV ; 3R45 ; 3UVW ; 3UVX ; 3UVY ; 3UW9 ; 3W96 ; 3W97 ; 3W98 ; 3W99 ; 3WA9 ; 3WAA ; 3WKJ ; 3WTP ; 3X1S ; 3X1T ; 3X1U ; 3X1V ; 4GQB ; 4H9N ; 4H9O ; 4H9P ; 4H9Q ; 4H9R ; 4H9S ; 4HGA ; 4M38 ; 4N3W ; 4N4F ; 4QUT ; 4QUU ; 4QYD ; 4U9W ; 4YM5 ; 4YM6 ; 4YY6 ; 4YYD ; 4YYG ; 4YYH ; 4YYI ; 4YYJ ; 4YYK ; 4YYM ; 4YYN ; 4Z2M ; 4Z5T ; 5AV5 ; 5AV6 ; 5AV8 ; 5AV9 ; 5AVB ; 5AVC ; 5AY8 ; 5B0Y ; 5B0Z ; 5B24 ; 5B2I ; 5B2J ; 5B31 ; 5B32 ; 5B33 ; 5B40 ; 5BNV ; 5BNX ; 5BO0 ; 5C3I ; 5CPI ; 5CPJ ; 5CPK ; 5FA5 ; 5FFW ; 5FWE ; 5GSE ; 5GSU ; 5GT0 ; 5GT3 ; 5GTC ; 5GXQ ; 5JA4 ; 5JRG ; 5KDM ; 5TEG ; 5X7X ; 5XF3 ; 5XF4 ; 5XF5 ; 5Y0C ; 5Y0D ; 5YE3 ; 5YE4 ; 5Z23 ; 5Z30 ; 5ZBX ; 5ZGC ; 6A5L ; 6A5O ; 6A5P ; 6A5R ; 6A5T ; 6A5U ; 6ACP ; 6BUZ ; 6C0W ; 6E0C ; 6E0P ; 6FML ; 6HKT ; 6HTS ; 6INQ ; 6IR9 ; 6J4W ; 6J4X ; 6J4Y ; 6J4Z ; 6J50 ; 6J51 ; 6JOU ; 6JR0 ; 6JR1 ; 6K1I ; 6K1J ; 6K1K ; 6KE9 ; 6KVD ; 6KXV ; 6L49 ; 6L4A ; 6L9H ; 6LA8 ; 6LA9 ; 6LE9 ; 6M3V ; 6M44 ; 6M4D ; 6M4G ; 6M4H ; 6MLC ; 6MUO ; 6MUP ; 6O1D ; 6R0C ; 6R8Y ; 6R8Z ; 6R90 ; 6R91 ; 6R92 ; 6R93 ; 6R94 ; 6RNY ; 6RXS ; 6SE0 ; 6SE6 ; 6SEE ; 6SEF ; 6SEG ; 6T79 ; 6T7A ; 6T7B ; 6T7C ; 6T7D ; 6T90 ; 6T93 ; 6UPK ; 6UPL ; 6USJ ; 6V2K ; 6V92 ; 6VO5 ; 6X59 ; 6X5A ; 6XJD ; 6Y5D ; 6YOV ; 7A08 ; 7C0M ; 7CCQ ; 7CCR ; 7DBP ; 7JO9 ; 7JOA ; 7K5X ; 7K5Y ; 7K60 ; 7K61 ; 7K63
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change H4C1 MORE protein abundance levels: increase (FC = 1.38)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the increase of H4C1 MORE protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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