Details of Protein

General Information of Protein (ID: PRT00405)
Name Bromodomain-containing protein 1 (BRD1)
Synonyms   Click to Show/Hide Synonyms of This Protein
BR140-like protein; Bromodomain and PHD finger-containing protein 2; BRD1; BRL; BRPF2
Gene Name BRD1 Gene ID
23774
UniProt ID
O95696
Family Acyl-CoA binding (ACB)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEII
LEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEP
KVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLA
VHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPE
VGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTV
RSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYW
LLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIE
LLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYL
DHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGG
VVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRE
LLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALG
PEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGL
GRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGN
YAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHN
GVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKM
MEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID
Structure
2KU3 ; 2L43 ; 2LQ6 ; 3LYI ; 3RCW ; 4Z02 ; 5AME ; 5AMF ; 5FG6 ; 5GK9 ; 5N49 ; 5PNX ; 5PNY ; 5PNZ ; 5PO0 ; 5PO1 ; 5PO2 ; 5PO3 ; 5PO4 ; 5PO5 ; 5PO6 ; 5PO7 ; 5PO8 ; 5PO9 ; 5POA ; 5POB ; 5POC ; 5POD ; 5POE ; 5POF ; 5POG ; 5POH ; 5POI ; 5POJ ; 5POK ; 5POL ; 5POM ; 5PON ; 5POO ; 5POP ; 5POQ ; 5POR ; 5POS ; 5POT ; 5POU ; 5POV ; 5POW ; 5POX ; 5POY ; 5POZ ; 5PP0 ; 5PP1 ; 5PP2 ; 5PP3 ; 5PP4 ; 5PP5 ; 5PP6 ; 5PP7 ; 5PP8 ; 5PP9 ; 5PPA ; 5PPB ; 5PPC ; 5PPD ; 5PPE ; 5PPF ; 5PPG ; 5PPH ; 5PPI ; 5PPJ ; 5PPK ; 5PPL ; 5PPM ; 5PPN ; 5PPO ; 5PPP ; 5PPQ ; 5PPR ; 5PPS ; 5PPT ; 5PPU ; 5PPV ; 5PPW ; 5PPX ; 5PPY ; 5PPZ ; 5PQ0 ; 5PQ1 ; 5PQ2 ; 5PQ3 ; 5PQ4 ; 5PQ5 ; 5PQ6 ; 5PQ7 ; 5PQ8 ; 5PQ9 ; 5PQA ; 5PQB ; 5PQC ; 5PQD ; 5PQE ; 5PQF ; 5PQG ; 5PQH ; 5PQI ; 5PQJ ; 5PQK ; 5PQL ; 5PQM ; 5PQN ; 5PQO ; 5PQP ; 5PQQ ; 5PQR ; 5PQS ; 5PQT ; 5PQU ; 5PQV ; 5PQW ; 5PQX ; 5PQY ; 5PQZ ; 5PR0 ; 5PR1 ; 5PR2 ; 5PR4 ; 5PR5 ; 5PR6 ; 5PR7 ; 5PR8 ; 5PR9 ; 5PRA ; 5PRB ; 5PRD ; 5PRE ; 5PRF ; 5PRG ; 5PRH ; 5PRI ; 5PRJ ; 5PRK ; 5PRL ; 5PRM ; 5PRO ; 5PRP ; 5PRQ ; 5PRR ; 5PRS ; 5PRT ; 5PRU ; 5PRV ; 5PRW ; 5PRX ; 5PRY ; 5PRZ ; 5PS0 ; 5PS1 ; 5PS2 ; 5PS3 ; 5PS4 ; 5PS5 ; 5PS6 ; 5PS7 ; 5PS8 ; 5PS9 ; 5PSA ; 5PSB ; 5PSC ; 5PSD ; 5PSE ; 5PSF ; 5PSG ; 5PSH ; 5PSI ; 5PSJ ; 5PSK ; 5PSL ; 5PSM ; 5PSN ; 5PSO ; 5PSP ; 5PSQ ; 5PSR ; 5PSS ; 5PST ; 5PSU ; 5PSV ; 5PSW ; 5PSX ; 5PSY ; 5PSZ ; 5PT0 ; 5PT1 ; 5PT2 ; 5PT3 ; 5PT4 ; 5PT5 ; 5PT6 ; 5PT7 ; 5PT8 ; 5PT9 ; 5PTA ; 5PTB ; 5PTC ; 5PTE ; 5PTF ; 5PTG ; 5PTH ; 5PTJ ; 5PTK ; 5PTL ; 5PTM ; 5PTN ; 5PTO ; 5PTQ ; 5PTR ; 5PTS ; 5PTT ; 5PTU ; 5PTV ; 5PTW ; 5PTX ; 5PTY ; 5PTZ ; 5PU0 ; 5PU1 ; 5PU2 ; 5PU3 ; 5PU4 ; 5PU5 ; 5PU6 ; 5PU7 ; 5PU8 ; 5PU9 ; 5PUA ; 5PUB ; 5PUC ; 5PUD ; 5PUE ; 5PUF ; 5PUG ; 5PUH ; 5PUI ; 5PUJ ; 5PUK ; 5PUL ; 5PUM ; 5PUN ; 5PUO ; 5PUP ; 5PUQ ; 5PUR ; 5PUS ; 5PUT ; 5PUU ; 5PUV ; 5PUW ; 5PUX ; 5PUY ; 5PUZ ; 5PV0 ; 5PV1 ; 5PV2 ; 5PV3 ; 5PV4 ; 5PV5 ; 5PV6 ; 5PV7 ; 5PV8 ; 5PV9 ; 5PVA ; 5PVB ; 5PVC ; 5PVD ; 5PVE ; 5PVF ; 5PVG ; 5PVH ; 5PVI ; 5PVJ ; 5PVK ; 5PVL ; 5PVM ; 5PVN ; 5PVO ; 5PVP ; 5PVQ ; 5PVR ; 5PVS ; 5PVT ; 5PVU ; 5PVV ; 5PVW ; 5PVX ; 5PVY ; 5PVZ ; 5PW0 ; 5PW1 ; 5PW2 ; 5PW3 ; 5PW4 ; 5PW5 ; 5PW6 ; 5PW7 ; 5PW8 ; 5PW9 ; 5PWA ; 5PWB ; 6IN2 ; 6MAJ ; 6MAK
Function Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change BRD1 protein abundance levels: increase (FC = 11.11)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the increase of BRD1 protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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