Details of Protein
| General Information of Protein (ID: PRT00387) | |||||
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| Name | COMM domain-containing protein 6 (COMMD6) | ||||
| Synonyms |
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MSTP076; COMMD6
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| Gene Name | COMMD6 | Gene ID | |||
| UniProt ID | |||||
| Family | COMM domain containing (COMM) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKC
FEMTIPQFQNFYRQFKEIAAVIETV |
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| Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Glutamine | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Glutamine addition (24 hours) | |||||
| Induced Change | COMMD6 protein expression levels: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Colon cancer [ICD-11: 2B90] | |||||
| Details | It is reported that glutamine addition causes the decrease of COMMD6 protein expression compared with control group. | |||||
| References | |||||
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| 1 | Glutamine regulates the human epithelial intestinal HCT-8 cell proteome under apoptotic conditions. Mol Cell Proteomics. 2007 Oct;6(10):1671-9. | ||||
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