Details of Protein

General Information of Protein (ID: PRT00383)
Name DDB1/CUL4-associated factor 13 (DCAF13)
Synonyms   Click to Show/Hide Synonyms of This Protein
WD repeat and SOF domain-containing protein 1; Dcaf13; Gm83; Wdsof1
Gene Name Dcaf13 Gene ID
223499
UniProt ID
Q6PAC3
Family WD repeat protein (WRP)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MKVKMLSRNPDNYVRETKLDIQRVPRNYDPTLHPFEVPREYVRALNATKLERVFAKPFLA
SLDGHRDGVNCLAKHPKSLASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFC
GTSFFTVGDDKTVKQWKMDGPGYGEEEEPLYTVLGKTVYTGIDHHWKDPVFATCGQQVDI
WDEQRTSPVCSMNWGFDSISSVKFNPVETFLLGSCASDRNIVLYDMRQATPLKKVILEMR
TNTICWNPMEAFNFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSA
SFDKSIRIFPVDKSRSREVYHTKRMQHVMCVKWTSDSKYIMCGSDEMNIRLWKANASEKL
GVLTSREKAANDYNQKLKEKFQYHPHVKRIARHRHLPKSIYSQIQEQRVMKEARRRKEMN
RRKHSKPGSVPIVSERKKHVVAVVK
Function Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose (low concentration) addition (17.50 hours)
                      Induced Change DCAF13 protein abundance levels: decrease (FC = 1.56)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Cerebral stroke [ICD-11: 8B11]
                      Details It is reported that low glucose addition causes the decrease of DCAF13 protein abundance compared with control group.
References
1 Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272.

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