Details of Protein

General Information of Protein (ID: PRT00364)
Name Proteasome component PRE5 (PRE5)
Synonyms   Click to Show/Hide Synonyms of This Protein
Macropain subunit PRE5; Multicatalytic endopeptidase complex subunit PRE5; Proteasome subunit alpha type-6 ; Proteinase YSCE subunit PRE5; YMR314W; YM9924.06; PRE5
Gene Name PRE5 Gene ID
855362
UniProt ID
P40302
Family Hydrolases (EC 3)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQ
KKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNT
QSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFI
KIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI
Structure
1FNT ; 1G0U ; 1G65 ; 1JD2 ; 1RYP ; 1Z7Q ; 2F16 ; 2FAK ; 2GPL ; 2ZCY ; 3BDM ; 3D29 ; 3DY3 ; 3DY4 ; 3E47 ; 3GPJ ; 3GPT ; 3GPW ; 3HYE ; 3JCO ; 3JCP ; 3MG0 ; 3MG4 ; 3MG6 ; 3MG7 ; 3MG8 ; 3NZJ ; 3NZW ; 3NZX ; 3OEU ; 3OEV ; 3OKJ ; 3SDI ; 3SDK ; 3SHJ ; 3TDD ; 3UN4 ; 3UN8 ; 3WXR ; 4CR2 ; 4CR3 ; 4CR4 ; 4EU2 ; 4FZC ; 4FZG ; 4G4S ; 4GK7 ; 4HNP ; 4HRC ; 4HRD ; 4INR ; 4INT ; 4INU ; 4J70 ; 4JSQ ; 4JSU ; 4JT0 ; 4LQI ; 4LTC ; 4NNN ; 4NNW ; 4NO1 ; 4NO6 ; 4NO8 ; 4NO9 ; 4Q1S ; 4QBY ; 4QLQ ; 4QLS ; 4QLT ; 4QLU ; 4QLV ; 4QUX ; 4QUY ; 4QV0 ; 4QV1 ; 4QV3 ; 4QV4 ; 4QV5 ; 4QV6 ; 4QV7 ; 4QV8 ; 4QV9 ; 4QVL ; 4QVM ; 4QVN ; 4QVP ; 4QVQ ; 4QVV ; 4QVW ; 4QVY ; 4QW0 ; 4QW1 ; 4QW3 ; 4QW4 ; 4QW5 ; 4QW6 ; 4QW7 ; 4QWF ; 4QWG ; 4QWI ; 4QWJ ; 4QWK ; 4QWL ; 4QWR ; 4QWS ; 4QWU ; 4QWX ; 4QXJ ; 4QZ0 ; 4QZ1 ; 4QZ2 ; 4QZ3 ; 4QZ4 ; 4QZ5 ; 4QZ6 ; 4QZ7 ; 4QZW ; 4QZX ; 4QZZ ; 4R00 ; 4R02 ; 4R17 ; 4R18 ; 4RUR ; 4V7O ; 4X6Z ; 4Y69 ; 4Y6A ; 4Y6V ; 4Y6Z ; 4Y70 ; 4Y74 ; 4Y75 ; 4Y77 ; 4Y78 ; 4Y7W ; 4Y7X ; 4Y7Y ; 4Y80 ; 4Y81 ; 4Y82 ; 4Y84 ; 4Y8G ; 4Y8H ; 4Y8I ; 4Y8J ; 4Y8K ; 4Y8L ; 4Y8M ; 4Y8N ; 4Y8O ; 4Y8P ; 4Y8Q ; 4Y8R ; 4Y8S ; 4Y8T ; 4Y8U ; 4Y9Y ; 4Y9Z ; 4YA0 ; 4YA1 ; 4YA2 ; 4YA3 ; 4YA4 ; 4YA5 ; 4YA7 ; 4YA9 ; 4Z1L ; 5A5B ; 5AHJ ; 5BOU ; 5BXL ; 5BXN ; 5CGF ; 5CGG ; 5CGH ; 5CGI ; 5CZ4 ; 5CZ5 ; 5CZ6 ; 5CZ7 ; 5CZ8 ; 5CZ9 ; 5CZA ; 5D0S ; 5D0T ; 5D0V ; 5D0W ; 5D0X ; 5D0Z ; 5DKI ; 5DKJ ; 5FG7 ; 5FG9 ; 5FGA ; 5FGD ; 5FGE ; 5FGF ; 5FGG ; 5FGH ; 5FGI ; 5FHS ; 5JHR ; 5JHS ; 5L52 ; 5L54 ; 5L55 ; 5L5A ; 5L5B ; 5L5D ; 5L5E ; 5L5F ; 5L5H ; 5L5I ; 5L5J ; 5L5O ; 5L5P ; 5L5Q ; 5L5R ; 5L5S ; 5L5T ; 5L5U ; 5L5V ; 5L5W ; 5L5X ; 5L5Y ; 5L5Z ; 5L60 ; 5L61 ; 5L62 ; 5L63 ; 5L64 ; 5L65 ; 5L66 ; 5L67 ; 5L68 ; 5L69 ; 5L6A ; 5L6B ; 5L6C ; 5LAI ; 5LAJ ; 5LTT ; 5M2B ; 5MP9 ; 5MPA ; 5MPB ; 5MPC ; 5NIF ; 5WVI ; 5WVK ; 6EF0 ; 6EF1 ; 6EF2 ; 6EF3 ; 6FVT ; 6FVU ; 6FVV ; 6FVW ; 6FVX ; 6FVY ; 6G7F ; 6G8M ; 6G8N ; 6GOP ; 6H39 ; 6HTB ; 6HTC ; 6HTD ; 6HTP ; 6HTR ; 6HUB ; 6HUC ; 6HUQ ; 6HUU ; 6HUV ; 6HV3 ; 6HV4 ; 6HV5 ; 6HV7 ; 6HVA ; 6HVR ; 6HVS ; 6HVT ; 6HVU ; 6HVV ; 6HVW ; 6HVX ; 6HVY ; 6HW0 ; 6HW3 ; 6HW4 ; 6HW5 ; 6HW6 ; 6HW7 ; 6HW8 ; 6HW9 ; 6HWA ; 6HWB ; 6HWC ; 6HWD ; 6HWE ; 6HWF ; 6J2C ; 6J2N ; 6J2Q ; 6J2X ; 6J30
Function The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Homogeneous non-metal compounds
            Nitrogen Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Nitrogen limitation (1.50 hours)
                      Induced Change PRE5 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that nitrogen limitation causes the increase of PRE5 protein expression compared with control group.
References
1 Proteome analysis of yeast response to various nutrient limitations. Mol Syst Biol. 2006;2:2006.0026.

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