Details of Protein
| General Information of Protein (ID: PRT00329) | |||||
|---|---|---|---|---|---|
| Name | Superoxide dismutase Cu-Zn (SOD Cu-Zn) | ||||
| Synonyms |
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Sod1
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| Gene Name | Sod1 | Gene ID | |||
| UniProt ID | |||||
| Family | Oxidoreductases (EC 1) | ||||
| EC Number | EC: 1.15.1.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MAMKAVCVLKGDGPVQGTIHFEQKASGEPVVLSGQITGLTEGQHGFHVHQYGDNTQGCTS
AGPHFNPHSKKHGGPADEERHVGDLGNVTAGKDGVANVSIEDRVISLSGEHSIIGRTMVV HEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ |
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| Structure | |||||
| Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Methionine | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Methionine decrease (504 hours) | |||||
| Induced Change | SOD1 protein expression levels: decrease (FC = 0.50) | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Fatty liver disease [ICD-11: DB92] | |||||
| Details | It is reported that methionine decrease causes the decrease of SOD1 protein expression compared with control group. | |||||
| References | |||||
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| 1 | Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577. | ||||
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