Details of Protein

General Information of Protein (ID: PRT00188)
Name 6-phosphogluconolactonase (PGLS)
Synonyms   Click to Show/Hide Synonyms of This Protein
6PGL; Pgls
Gene Name Pgls Gene ID
66171
UniProt ID
Q9CQ60
Family Hydrolases (EC 3)
EC Number   EC: 3.1.1.31  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.31
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MAAPAPSLISVFSSPQELGASLAQLVAQRAASCLEGDRGRFALGLSGGSLVSMLARDLPA
AAAPAGPASFARWTLGFCDERLVPFDHAESTYGLYRTHLLSKLPIPDSQVLTINPALPVE
DAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPK
PPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLPAALVQPRTGALCWFLD
EAAARLLSVPFEKHSTL
Function Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine addition (336 hours)
                      Induced Change PGLS protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hyperhomocysteinaemia [ICD-11: 3B61]
                      Details It is reported that methionine addition causes the increase of PGLS protein expression compared with control group.
References
1 The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics. 2010 Mar;9(3):471-85.

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