Details of Protein

General Information of Protein (ID: PRT00116)
Name Albumin (ALB)
Synonyms   Click to Show/Hide Synonyms of This Protein
GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341; ALB
Gene Name ALB Gene ID
213
UniProt ID
P02768
Family Serum albumin (ALB)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Structure
1AO6 ; 1BJ5 ; 1BKE ; 1BM0 ; 1E78 ; 1E7A ; 1E7B ; 1E7C ; 1E7E ; 1E7F ; 1E7G ; 1E7H ; 1E7I ; 1GNI ; 1GNJ ; 1H9Z ; 1HA2 ; 1HK1 ; 1HK2 ; 1HK3 ; 1HK4 ; 1HK5 ; 1N5U ; 1O9X ; 1TF0 ; 1UOR ; 1YSX ; 2BX8 ; 2BXA ; 2BXB ; 2BXC ; 2BXD ; 2BXE ; 2BXF ; 2BXG ; 2BXH ; 2BXI ; 2BXK ; 2BXL ; 2BXM ; 2BXN ; 2BXO ; 2BXP ; 2BXQ ; 2ESG ; 2I2Z ; 2I30 ; 2N0X ; 2VDB ; 2VUE ; 2VUF ; 2XSI ; 2XVQ ; 2XVU ; 2XVV ; 2XVW ; 2XW0 ; 2XW1 ; 2YDF ; 3A73 ; 3B9L ; 3B9M ; 3CX9 ; 3JQZ ; 3JRY ; 3LU6 ; 3LU7 ; 3LU8 ; 3SQJ ; 3TDL ; 3UIV ; 4BKE ; 4E99 ; 4EMX ; 4G03 ; 4G04 ; 4HGK ; 4HGM ; 4IW1 ; 4IW2 ; 4K2C ; 4K71 ; 4L8U ; 4L9K ; 4L9Q ; 4LA0 ; 4LB2 ; 4LB9 ; 4N0F ; 4N0U ; 4S1Y ; 4Z69 ; 5FUO ; 5GIX ; 5GIY ; 5ID7 ; 5IFO ; 5IJF ; 5UJB ; 5VNW ; 5X52 ; 5YB1 ; 5YOQ ; 5Z0B ; 6A7P ; 6EZQ ; 6HSC ; 6JE7 ; 6L4K ; 6M58 ; 6M5D ; 6M5E ; 6QIO ; 6QIP ; 6R7S ; 6WUW ; 6XV0 ; 6YG9 ; 7JWN
Function Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Oxoglutaric acid Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Oxoglutaric acid addition (336 hours)
                      Induced Change ALB protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Parkinsonism [ICD-11: 8A00]
                      Details It is reported that oxoglutaric acid addition causes the increase of ALB protein expression compared with control group.
References
1 Dietary keto-acid feed-back on pituitary activity in gilthead sea bream: effects of oral doses of AKG. A proteomic approach. Gen Comp Endocrinol. 2010 Dec 1;169(3):284-92.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.