Details of Protein

General Information of Protein (ID: PRT00086)
Name Insulin-2 (INS2)
Synonyms   Click to Show/Hide Synonyms of This Protein
Ins2; Ins-2
Gene Name Ins2 Gene ID
24506
UniProt ID
P01323
Family Insulin (Insu)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MALWIRFLPLLALLILWEPRPAQAFVKQHLCGSHLVEALYLVCGERGFFYTPMSRREVED
PQVAQLELGGGPGAGDLQTLALEVARQKRGIVDQCCTSICSLYQLENYCN
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Leucine Click to Show/Hide the Full List of Regulating Pair(s):   3 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Leucine addition (288 hours)
                      Induced Change INS2 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that leucine addition causes the increase of INS2 protein expression compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Leucine addition (72 hours)
                      Induced Change INS2 mRNAlevel levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that leucine addition causes the increase of INS2 mRNA levels compared with control group.
               Regulating Pair (3) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Leucine addition (72 hours)
                      Induced Change INS2 protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that leucine addition causes the decrease of INS2 protein expression compared with control group.
References
1 Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E621-30.
2 Chronic exposure to leucine in vitro induces -cell dysfunction in INS-1E cells and mouse islets. J Endocrinol. 2012 Oct;215(1):79-88.

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