Details of Protein

General Information of Protein (ID: PRT00008)
Name Deoxyribonuclease TATDN1 (TATDN1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Tatdn1
Gene Name Tatdn1 Gene ID
69694
UniProt ID
Q6P8M1
Family Hydrolases (EC 3)
EC Number   EC: 3.1.21.-  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
5'-Phosphomonoesters endodeoxyribonucleases
EC: 3.1.21.-
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSLFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAIQIGVKKFMITGGSLQDSKDA
LQLAQTNDMFFSTVGCHPTRCDEFEKGSPDQYLAGLLSLAENNKGKVVAIGECGLDFDRL
QFCPKDTQLKYFEKQFELSEQTQLPMFLHCRNSHTEFLDIMRRNRDRYVGGVVHSFDGTK
EAAAALVDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYINT
SFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVREEDPLELANTLYNNTIKVFFS
Function Putative deoxyribonuclease.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change TATDN1 protein expression levels: increase (FC = 1.85)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the increase of TATDN1 protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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