Details of Protein
| General Information of Protein (ID: PRT00005) | |||||
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| Name | Serine/threonine-protein kinase tousled-like 1 (TLK1) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
Tousled-like kinase 1; Tlk1
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| Gene Name | Tlk1 | Gene ID | |||
| UniProt ID | |||||
| Family | Transferases (EC 2) | ||||
| EC Number | EC: 2.7.11.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQ
ELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESS RGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTP SSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTMLKLAALESTKNQDLEKKEGRID DLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRL GHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTANNSQAP ATNSEAKQRKTKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAE LERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQR YAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEY CEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC GEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV GVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKE DRFDVHQLANDPYLLPHMRRSNSSGNLHMSGLTATPTPPSSSIITY |
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| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic oxygen compounds | ||||||
| Glucose | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Glucose (low concentration) addition (17.50 hours) | |||||
| Induced Change | TLK1 protein abundance levels: increase (FC = 1.70) | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cerebral stroke [ICD-11: 8B11] | |||||
| Details | It is reported that low glucose addition causes the increase of TLK1 protein abundance compared with control group. | |||||
| References | |||||
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| 1 | Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272. | ||||
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