| Regulating Pair |
| Introduced Variation |
Inhibition (968) of GLS1 |
Protein Info
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| Induced Change |
Glutamine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glutamine concentration after inhibition (968) of GLS1 through kit. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
A549 cells (Human non-small cell lung carcinoma cells) |
Lung |
| Subcellular Location |
Cytoplasm (cytosol); Mitochondrion (Mitochondrion matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition (968) of GLS1 leads to the decrease of glutamine levels compared with control group. |
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| References |
| 1 |
Phosphorylation of glutaminase by PKC is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Res. 2018 Jun;28(6):655-669.
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