| Regulating Pair |
| Introduced Variation |
Overexpression of GLS1 |
Protein Info
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| Induced Change |
Glutamine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glutamine concentration after overexpression of GLS1 through kit. |
| Disease Status |
Prostate cancer |
ICD-11: 2C82 |
| Organ/Tissue/Cell Line |
PC3 cells (Prostate cancer cells) |
Prostate |
| Subcellular Location |
Cytoplasm (cytosol); Mitochondrion (Mitochondrion matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of GLS1 leads to the increase of glutamine levels compared with control group. |
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| References |
| 1 |
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009 Apr 9;458(7239):762-5.
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