| Regulating Pair |
| Introduced Variation |
Knockout of Gcgr |
Protein Info
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| Induced Change |
Oxoglutaric acid concentration: increase (FC = 2.3) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of oxoglutaric acid concentration after GCGR knockout through LC/MS/MRM based metabolomics. |
| Disease Status |
Type 2 diabetes mellitus |
ICD-11: 5A11 |
| Organ/Tissue/Cell Line |
N.A. |
Plasma |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of GCGR leads to the increase of oxoglutaric acid levels compared with control group. |
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| References |
| 1 |
Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics. 2011 Jun 1;12:281.
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