| Regulating Pair |
| Introduced Variation |
Downregulation of slc2a1a caused by Yap loss-of-function mutation |
Protein Info
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| Induced Change |
Guanosine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of guanosine concentration after slc2a1a mutation (yap -/-) through LC/MSMS;SRM analysis based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Embryos |
| Tested Species |
Species: Danio rerio (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Danionidae
Genus: Danio
Species: Danio rerio
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| Details |
It is reported that downregulation of slc2a1a caused by Yap loss-of-function mutation leads to the decrease of guanosine levels compared with control group. |
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| References |
| 1 |
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018 Nov 15;37(22):e100294.
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