| Regulating Pair |
| Introduced Variation |
Knockout of Naglu |
Protein Info
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| Induced Change |
5-Hydroxyindoleacetic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 5-hydroxyindoleacetic acid concentration after Naglu knockout through ultrahigh-performance LC-MS/MS (UPLC-MS/MS) based metabolomics. |
| Disease Status |
Lysosomal storage diseases |
ICD-11: 5C56 |
| Organ/Tissue/Cell Line |
N.A. |
Serum |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Naglu leads to the decrease of 5-hydroxyindoleacetic acid levels compared with control group. |
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| References |
| 1 |
Near-Complete Correction of Profound Metabolomic Impairments Corresponding to Functional Benefit in MPS IIIB Mice after IV rAAV9-hNAGLU Gene Delivery. Mol Ther. 2017 Mar 1;25(3):792-802.
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