| Regulating Pair |
| Introduced Variation |
Inhibition (G007-LK) of Tnks |
Protein Info
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| Induced Change |
Cholesterol concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cholesterol concentration after Tnks inhibition through kit detection. based metabolomics. |
| Disease Status |
Diabetes mellitus |
ICD-11: 5A14 |
| Organ/Tissue/Cell Line |
N.A. |
Serum |
| Subcellular Location |
Cytoplasm; Golgi apparatus (Golgi apparatus membrane); Cytoplasm (Cytoskeleton); Centrosome; Nucleus (Nuclear pore complex; Chromosome; Telomere) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that inhibition of Tnks leads to the decrease of cholesterol levels compared with control group. |
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| References |
| 1 |
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 PARylation in db/db mice. Int J Obes (Lond). 2020 Aug;44(8):1691-1702.
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