| Regulating Pair |
| Introduced Variation |
Knockout of L2hgdh |
Protein Info
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| Induced Change |
Glutamine concentration: decrease (FC= 0.55) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-glutamine concentration after L2hgdh knockout through LC/MS/MS based metabolomics. |
| Disease Status |
Organic acid disorderss |
ICD-11: 5C50 |
| Organ/Tissue/Cell Line |
N.A. |
Brain |
| Subcellular Location |
Mitochondrion |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of L2hgdh leads to the decrease of glutamine levels compared with control group. |
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| References |
| 1 |
A mouse model of L-2-hydroxyglutaric aciduria, a disorder of metabolite repair. PLoS One. 2015 Mar 12;10(3):e0119540.
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