| Regulating Pair |
| Introduced Variation |
Knockout of Nat2 |
Protein Info
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| Induced Change |
INH-vitamin B6 (PL) concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of INH-vitamin B6 (PL) concentration after NAT knockout through Ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-TOFMS) based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of NAT leads to the increase of INH-vitamin B6 (PL) levels compared with control group. |
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| References |
| 1 |
Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017 Dec 1;145:218-225.
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