| Regulating Pair |
| Introduced Variation |
Knockout of Ppara |
Protein Info
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| Induced Change |
Cholic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cholic acid concentration after Ppara knockout through nano-UPLC Q-TOF MS/MS ACQUITY UPLC based metabolomics. |
| Disease Status |
Healthy individual |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ppara leads to the increase of cholic acid levels compared with control group. |
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| References |
| 1 |
Targeted Metabolomics Reveals a Protective Role for Basal PPAR in Cholestasis Induced by -Naphthylisothiocyanate. J Proteome Res. 2018 Apr 6;17(4):1500-1508.
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