| Regulating Pair |
| Introduced Variation |
Knockout of Ggps1 |
Protein Info
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| Induced Change |
Bile acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of bile acid concentration after Ggps1 knockout through Liquid chromatography/mass spectrometry based metabolomics. |
| Disease Status |
Metabolic liver disease |
ICD-11: 5C90 |
| Organ/Tissue/Cell Line |
N.A. |
Serum |
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Liver |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ggps1 leads to the decrease of bile acid levels compared with control group. |
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| References |
| 1 |
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism. FEBS J. 2020 Aug;287(15):3328-3345.
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