Regulating Pair
       Introduced Variation Overexpression of SLC44A4 Protein Info
       Induced Change Thiamine pyrophosphate concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of thiamine pyrophosphate concentration after SLC44A4 overexpression through 3H- or 14C-labeled amino acids assay.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line ARPE19 cells ( Retinal pigment epithelium cells) Retinal pigment epithelium
       Subcellular Location Membrane (Apical cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC44A4 leads to the increase of thiamine pyrophosphate levels compared with control group in ARPE19 cells.
References
1 Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2014 Feb 14;289(7):4405-16.

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