| Regulating Pair |
| Introduced Variation |
Overexpression of Foxo1 |
Protein Info
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| Induced Change |
CMP-N-Acetylneuraminate concentration: increase (FC = 1.20) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cytidine 5'-monophosphate-N-acetylneuraminic acid concentration after Foxo1 overexpression through CETOFMS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
C2C12 cells (Mouse skeletal muscle cells) |
Muscle |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that overexpression of Foxo1 leads to the increase of CMP-N-acetylneuraminate levels compared with control group in C2C12 cells. |
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| References |
| 1 |
Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
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