| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of SLC26A6 |
Protein Info
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| Induced Change |
Oxalic acid concentration: decrease (FC = 0.60) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of oxalic acid concentration after SLC26A6 knockdown through kit detection. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
Caco-2 cells (Colorectal adenocarcinoma cells) |
Colorectal |
| Subcellular Location |
Membrane (Cell membrane; Apical cell membrane); Cytoplasm (Cytoplasmic vesicle membrane); Microsome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of SLC26A6 leads to the decrease of oxalic acid levels compared with control group in Caco-2 cells. |
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| References |
| 1 |
Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1. Am J Physiol Gastrointest Liver Physiol. 2009 Nov;297(5):G918-29.
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