| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of SNRK |
Protein Info
|
| Induced Change |
Malic acid concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after SNRK knockdown through NMR analysis based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Cardiomyocytes |
Heart |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that knockdown of SNRK leads to the decrease of malic acid levels compared with control group in cardiomyocytes. |
|
|
|
|
|
|
|
| References |
| 1 |
Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function. Circ Cardiovasc Genet. 2016 Dec;9(6):474-486.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
