| Regulating Pair |
| Introduced Variation |
Overexpression of SLC7A8 |
Protein Info
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| Induced Change |
Leucine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1], [2], [3] |
| Method |
Quantifying the change of L-leucine concentration after SLC7A8 overexpression through [3H]labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS1 cells (Immortalized African monkey kidney cells) |
Kidney |
| Subcellular Location |
Cytoplasm; Membrane (Basolateral cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC7A8 leads to the increase of leucine levels compared with control group in COS1 cells and Xenopus laevis oocytes. |
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| References |
| 1 |
Transport of Iodothyronines by Human L-Type Amino Acid Transporters. Endocrinology. 2015 Nov;156(11):4345-55.
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| 2 |
The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):787-95.
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| 3 |
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta. 2001 Oct 1;1514(2):291-302.
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