Regulating Pair
       Introduced Variation Overexpression of SLC22A7 Protein Info
       Induced Change Oxoglutaric acid concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of oxoglutaric acid concentration after SLC22A7 overexpression through [3H]labeled amino acids kit detection.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line EcR293 cells (Human embryonic kidney cells) Kidney
Human embryonic kidney cells (HEK293) Kidney
       Subcellular Location Membrane (Basolateral cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC22A7 leads to the increase of oxoglutaric acid levels compared with control group in EcR293 cells and human embryonic kidney cells.
References
1 Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802.

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