| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of PKM |
Protein Info
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| Induced Change |
Serine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-serine concentration after PKM knockdown through LC-MS based metabolomics. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
H1299 cells (Human lung cancer cells) |
Lung |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of PKM leads to the increase of serine levels compared with control group in H1299 cells. |
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| References |
| 1 |
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chem Biol. 2012 Sep 21;19(9):1187-98.
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