| Regulating Pair |
| Introduced Variation |
Knockout of TP53 |
Protein Info
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| Induced Change |
cis-Aconitic acid concentration: increase (Log2 FC=1.18) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cis-aconitic acid concentration after TP53 knockout through UPLC/Q-TOF MS based metabolomics. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
HCT116 cells (Human colon carcinoma cells) |
Colon |
| Subcellular Location |
Nucleus (PML body); Endoplasmic reticulum; Mitochondrion (Mitochondrion matrix); Cytoplasm (Cytoskeleton); Centrosome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of TP53 leads to the increase of cis-aconitic acid levels compared with control group in HCT116 cells. |
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| References |
| 1 |
Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.
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