| Regulating Pair |
| Introduced Variation |
Knockout of HIF1A |
Protein Info
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| Induced Change |
Glycerol concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glycerol concentration after HIF1A knockout through 1H-NMR based metabolomics. |
| Disease Status |
Colorectal cancer |
ICD-11: 2B91 |
| Organ/Tissue/Cell Line |
HCT116 cells (Human colon carcinoma cells) |
Colon |
| Subcellular Location |
Cytoplasm; Nucleus (Nucleus speckle) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of HIF1A leads to the increase of glycerol levels compared with control group in HCT116 cells. |
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| References |
| 1 |
Hypoxia induces a lipogenic cancer cell phenotype via HIF1-dependent and -independent pathways. Oncotarget. 2015 Feb 10;6(4):1920-41.
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