| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of IDH3A |
Protein Info
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| Induced Change |
Lactic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after IDH3A knockdown through kit detection. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Mitochondrion |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of IDH3A leads to the decrease of lactic acid levels compared with control group in HEK293 cells. |
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| References |
| 1 |
Effect of IDH3a on glucose uptake in lung adenocarcinoma: A pilot study based on [ 18 F]FDG. Cancer Med. 2019 Sep;8(11):5341-5351.
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