| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of LKR/SDH |
Protein Info
|
| Induced Change |
Succinic acid concentration: increase |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of succinic acid concentration after LKR/SDH knockdown through Gas chromatography-mass spectrometry (GCMS) based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Arabidopsis thaliana (Click to Show/Hide the Complete Species Lineage)
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Brassicales
Family: Brassicaceae
Genus: Arabidopsis
Species: Arabidopsis thaliana
|
| Details |
It is reported that knockdown of LKR/SDH leads to the increase of succinic acid levels compared with control group in HEK293 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005 Jan;7(1):77-85.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
