| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of OXCT1 |
Protein Info
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| Induced Change |
Citric acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of citric acid concentration after OXCT1 knockdown through GC-MS based metabolomics. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
HepG2 cells (Human hepatoma cells) |
Liver |
| Subcellular Location |
Mitochondrion (Mitochondrion matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of OXCT1 leads to the decrease of citric acid levels compared with control group in HepG2 cells. |
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| References |
| 1 |
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res. 2016 Oct;26(10):1112-1130.
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