| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after OXCT1 overexpression through GC-MS based metabolomics. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
HepG2 cells (Human hepatoma cells) |
Liver |
| Hep3B (Human hepatoma cells) |
Liver |
| THLE3 cells (Primary normal liver cells) |
Liver |
| Subcellular Location |
Mitochondrion (Mitochondrion matrix) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of OXCT1 leads to the increase of malic acid levels compared with control group in HepG2 cells, Hep3B and THLE3 cells. |
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Induced Change