| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of NAT1 |
Protein Info
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| Induced Change |
Methionine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of racemethionine concentration after NAT1 knockdown through liquid chromatographymass spectrometry (LCMS/MS) |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
HT-29 cells (Human colon carcinoma cells) |
Colon |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of NAT1 leads to the decrease of methionine levels compared with control group in HT-29 cells. |
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| References |
| 1 |
Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway. Biochem Pharmacol. 2017 Feb 1;125:93-100.
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