| Regulating Pair |
| Introduced Variation |
Knockout of KMT2D |
Protein Info
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| Induced Change |
Citric acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of citric acid concentration after KMT2D knockout through LCMS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Human skin-derived fibroblast cells |
Skin |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of KMT2D leads to the increase of citric acid levels compared with control group in human skin-derived fibroblast cells. |
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| References |
| 1 |
Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration. Cells. 2020 Jul 13;9(7):1685.
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