| Regulating Pair |
| Introduced Variation |
Knockout of Sirt5 |
Protein Info
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| Induced Change |
Malic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after Sirt5 knockout through LC-MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Intestinal stem cells |
Intestine |
| Subcellular Location |
Mitochondrion; Cytoplasm (Cytosol); Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Sirt5 leads to the decrease of malic acid levels compared with control group in Intestinal stem cells. |
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| References |
| 1 |
HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice. Gastroenterology. 2020 Mar;158(4):985-999.e9.
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