| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of Pfkfb4 |
Protein Info
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| Induced Change |
ATP concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of adenosine triphosphate concentration after Pfkfb4 knockdown through kit detection. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
Lung fibroblasts |
Lung |
| Subcellular Location |
Cytoplasm (Cytosol) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockdown of Pfkfb4 leads to the decrease of ATP levels compared with control group in Lung fibroblasts. |
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| References |
| 1 |
Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget. 2014 Aug 30;5(16):6670-86.
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