| Regulating Pair |
| Introduced Variation |
Overexpression of PHGDH |
Protein Info
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| Induced Change |
Glycine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glycine concentration after PHGDH overexpression through gas-Chromatography Mass Spectrometry (GC/MS) based metabolomics. |
| Disease Status |
Breast cancer |
ICD-11: 2C60 |
| Organ/Tissue/Cell Line |
MCF-10A cells (Human mammary epithelial cells) |
Breast |
| Subcellular Location |
Cytoplasm (Cytosol; Extracellular exosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of PHGDH leads to the increase of glycine levels compared with control group in MCF-10A cells. |
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| References |
| 1 |
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31;43(9):869-74.
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