| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of tripeptide l-ala-gamma-d-glu-meso-DAP concentration after SLC15A4 mutation (L14A, L15A;L318A, V319A) through HPLC-MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
MDCK cells (Madin-Darby Canine Kidney cells) |
Kidney |
| Subcellular Location |
Lysosome (Lysosome membrane); Endosome (Early endosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (L14A and L15A or L318A and V319A) of SLC15A4 leads to the increase of tripeptide l-Ala-gamma-d-Glu-meso-DAP levels compared with control group in MDCK cells. |
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Induced Change