| Regulating Pair |
| Introduced Variation |
Overexpression of Slc4a4 |
Protein Info
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| Induced Change |
Lactic acid concentration: decrease (FC = 0.37) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after Slc4a4 overexpression through FRET-based nanosensor Laconic based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Mouse Astrocytes |
Brain |
| Subcellular Location |
Membrane (Basolateral cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that overexpression of Slc4a4 leads to the decrease of lactic acid levels compared with control group in mouse Astrocytes. |
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| References |
| 1 |
Inhibition of monocarboxylate transporter by N-cyanosulphonamide S0859. Eur J Pharmacol. 2015 Sep 5;762:344-9.
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